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KMID : 1123920110250050863
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Korean Journal of Oriental Physiology and Pathology
2011 Volume.25 No. 5 p.863 ~ p.869
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Effect of Acorus Gramineus on the Relaxation of Corpus Cavernosum Smooth Muscle
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Li Xiang
Kim Ho-Tae
Lee Jae-Yun
Lee Yun-Jung
Kang Dae-Gil
Lee Ho-Sub
Shin Hong-Kyun
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Abstract
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The aim of the present study is to investigate whether an ethanol extract of Acorus gramineus Soland (EAG) augments penile erection in vitro and in vivo experiment. Preconstructed with phenylephrine (PE) in isolated endothelium-intact rabbit corpus cavernosum, EAG relaxed penile smooth muscle in a dose-dependent manner, which was inhibited by pretreatment with NG-nitro-L-argininemethylester (L-NAME), a nitricoxide synthase inhibitor, and 1H-[1,2,4]-oxadiazole-[4,3-]-quinoxalin-1-one (ODQ), a soluble guanylylcyclase (sGC) inhibitor, respectively. EAG-induced relaxation was significantly attenuated by pretreatment with tetraethylammonium (TEA), a nonselective K+ channel blocker. EAG increased cGMP levels of the rabbit corpus cavernosum in a concentration-dependent manner without changes in cAMP levels. In addition, EAG caused increase of peak intracavernous pressure (ICP), ICP/MAP ratio and area under the carve (AUC) in SD rats. Taken together, these results suggest that EAG augments penile erection via NO-cGMP system and K+ channels in corpus cavernosum.
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KEYWORD
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Acorus gramineus, corpus cavernosum, NO/cGMP, K+ channel, ICP
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